4528                POST-NECROTIC SCARRING

The patient was a woman aged 29 who had progressively deepening jaundice for 6 months. On admission there was oedema of the legs and ascites. Laparotomy was performed for umbilical hernia. She died suddenly after the operation, and at post-mortem a large intra-peritoneal haemorrhage was found. The liver was small, shrunken and deformed and the spleen was small and soft (weight 150 gms).

The specimen consists of the liver which is somewhat reduced in size and shows very large rounded regeneration nodules, probably as a consequence of viral hepatitis. Histology shows broad zones of collapsed reticulum containing proliferated bile ducts, and chronic inflammatory cells. Large regeneration nodules comprise several lobules, many of which show some central patchy necrosis.